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It is found to be present in the body for a significant period of time after the required doses. Azithromycin works against several different bacteria, especially chlamydia and streptococcus. Zithromax is an azalide antibiotic, a subclass of the macrolides. Common side effects of Azithromycin are normally well tolerated. It is prescribed for adults to treat certain mild to moderate skin infections. There is a possibility of rare but very serious reactions to Zithromax, and serious skin diseases. In the abdomen.