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Corticosteroids become exaggerated and may be observed as side effects of this medicine. Corticosteroids reduce the normal response of the immune system and prevent the body from rejecting transplanted organs. Prednisone and Prednisolone are considered to be intermediate acting steroids, meaning that a dose lasts about a day or a day and a half. Prednisone and Prednisolone are members of the glucocorticoid class of hormones. Prednisone most often is used for treating allergies, arthritis, breathing problems, certain blood disorders, certain eye diseases, cancer or psoriasis. Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired. Before taking Prednisolone, you should tell your doctor about all of your medical conditions and about all other medicines you are using.