Diflucan is usually taken by mouth as a one-time only dose with or without food or as directed by your doctor. Fluconazole appears to be a safe and effective treatment for cutaneous leishmaniasis. In moderation while taking Diflucan. Fluconazole is one of the first-line drugs, particularly in treatment of infections. Fluconazole works best if it is taken at the same time each day. Diflucan comes as a tablet and liquid to take by mouth.
