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Synthroid can also reduce the effects of digitalis glycosides, which might require an increase in dosage. Synthroid is a naturally occurring hormone produced by the thyroid glands also known as goiter. Synthroid should be used only by the patient for whom it is prescribed. Take Synthroid as a single dose, preferably on an empty stomach, one-half to one hour before breakfast. Thyroid causes all kinds of issues and Levothyroxine replaces what your thyroid doesn't produce.