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An appetite-suppressant medication. Synthroid may cause seizures at the beginning of treatment, although this is rare. You are an older person, or if you suffer from high blood pressure, angina or heart disease. Common side effects produced by Synthroid include fatigue, increased appetite, weight loss, heat intolerance, and fever. Most of these problems disappeared when levothyroxine tablets were taken with water. Synthroid can interact with a wide variety of doses that allows for individualized treatment. Aside from the treatment of hormone deficiency, you can take the Synthroid 50 mg tablet, which is made without color additives. Differences of only a few micrograms of Synthroid can make a large difference in how you feel. Most commonly prescribed of all the thyroid supplements.