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Use this medication. Nexium is available in a powdered intravenous formulation to be reconstituted for injection. Nexium is usually taken once a day at least one hour before a meal. Esomeprazole prevents symptoms and damage to the gastrointestinal tract caused by stomach acid or infection. By excess stomach acid. Esomeprazole is used to treat ulcers, gastroesophageal reflux disease, Esomeprazole has demonstrated pharmacological and clinical benefits beyond those seen with the other proton pump inhibitors.