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Esomeprazole capsules should be taken at least one hour before meals and at the same time every day. Nexium is available in a powdered intravenous formulation to be reconstituted for injection. For injection. Nexium capsules should be applied one hour before meals and at the same time every day. What should my health care professional know before I take Esomeprazole? Esomeprazole works best if taken on an empty stomach at least one hour before meals and at the same time every day. Nexium decreases the amount of acid backing up into the esophagus and causing reflux symptoms. If taken on an empty stomach at least one hour before meals and at the same time every day. Esomeprazole capsules should be applied one hour before meals and at the same time every day.

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