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How is daily therapy different from taking Valtrex to treat each outbreak? Valtrex is also believed to reduce the risk of spreading genital herpes. Genital herpes, and also about Valtrex, the only once-daily medicine that can help reduce the number of outbreaks experienced in a year's time. Genital herpes not only recurs, it can be passed on to sexual partners. Genital herpes outbreaks as they happen, the standard dose of Valaciclovir is 500 mg twice daily for 3 full days. Valtrex can greatly decrease the length of time you experience an outbreak and may possibly reduce the number of incidences. Once-daily Valtrex is also the only medication proven to reduce the risk of spreading genital herpes. Probably the most common adverse reactions to the drug are headache, nausea, diarrhea, and vomiting.