Glucophage lowers the amount of sugar in your blood. Metformin is used as a first line treatment of type 2 diabetes. Most obese patients are insulin resistant, and increasingly the type-2 diabetes medication Metformin is being prescribed to increase glucose sensitivity and promote weight loss process. If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal or as directed by your doctor. Metformin can be used in combination with other anti-diabetic medicines to provide better control of blood sugar. Metformin comes as a tablet and an extended-release tablet to take by mouth. Metformin belongs to the class of drugs known as biguanides.