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Metformin can be used in combination with other anti-diabetic medicines to provide better control of blood sugar. If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal. Metformin increases the sensitivity of muscle cells to insulin. Most obese patients are insulin resistant, and increasingly the type-2 diabetes medication Metformin is being prescribed to increase glucose sensitivity and promote weight loss process. Glucophage should be taken with meals. Glucophage is used to control blood sugar levels. Glucophage lowers the amount of glucose you absorb from your food and the amount of sugar produced by cells in the liver.