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Lexapro affects chemicals in the brain, is an important factor in the development and severity of depressive symptoms, such as sad mood, fatigue, lack of pleasure, etc. Escitalopram appears to relieve depression by increasing serotonin levels with minimal effect on many of the other chemicals in the brain believed to influence mood. Lexapro is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors. If left untreated, can cause major problems in your life. Escitalopram helps to restore the brain's chemical balance by increasing the available supply of serotonin, a substance in the brain that may become unbalanced and cause depression or anxiety. Lexapro works by increasing the amount of serotonin, Escitalopram improves symptoms of depression.